My 6th residence at the Stellenbosch Institute For Advanced Study (STIAS), and the 3rd of my Permanent Fellowship, has begun. My project here will be a continuation of my first residence in 2015 “New approaches to anti-obesity therapeutics”.
During my first 2015 residence, I presented some of the approaches followed by my laboratory to investigate this problem, based on studies of the ALK7 protein, a highly abundant receptor molecule in rodent and human adipocytes that is a key regulator of fat metabolism and plasticity. Major advances have taken place in the past 9 years in the field as a whole, the best known of these being the development and clinical application of GLP-1 agonists.