Former postdoc fellow Svend Kjaer has today published his first first-author paper after leaving the lab. It has appeared online at the Nature Structure and Molecular Biology website. He’s got the first glimpse of the three-dimensional structure of the extracellular domain of the RET receptor, giving insights into how it binds ligand and how its mutation causes disease. Something we were striving to see for several years while he was at our lab has now been achieved and it’s one of the great success stories of making science. It took a lot of perseverance, a good measure of ingenuity and the crucial guidance and support of Svend’s current mentor and common friend Neil McDonald from the CRUK institute in London. As if by coincidence, from Svend comes also this link to the one-hour film “Naturally Obsessed: The Making of a Scientist” telling the story of three graduate students in a crystallography lab at Columbia University, NYC and their road to success (or failure) through “years of trial and error and unflinching dedication”. It gives good insights into real science making in a lab, the elusive thrill of its ups and downs, and what it takes to get to the finish line. Link from the picture above.
I am often asked why I shoot my photographs in RAW format. RAW capture refers to the direct transfer of the information acquired by the sensor of a digital camera to the memory card without any in-camera processing. In the 18-megapixel Canon EOS 7D, this translates into files of 25MB, compared to the 6MB of a high-resolution JPG-compressed file. Why would one like to shoot RAW files? The RAW format contains all the information captured by the sensor and is therefore most amenable to corrections of exposure, saturation, chromatic aberrations and noise during post-processing. Compressed JPG files contain a reduced amount of information and so are much more limited to adjust during post-processing. Why would someone want to adjust a photograph? Shown below are three examples taken during a recent trip to the Otavalo valley in Northern Ecuador. In all cases, the top image is straight-out-of-camera, while the lower image is after conversion in Adobe CS4 Camera Raw (no Photoshop in any of these examples!).